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Dispersed chromosomal Stat5b-binding elements mediate growth hormone-activated insulin-like growth factor-I gene transcription

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Changes in gut microbiota composition, microbial translocation, and disruptions in intestinal barrier integrity can influence CYP2E1 and lipid metabolism, and interfere with normal liver physiology, leading to pathological changes, such as liver inflammation and fibrosis (Maccioni et al., 2020)